False memories prime immune system for future attacks









































IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.












When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.












Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.












The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.












The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."












So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.












To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).












The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.












"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"












This article appeared in print under the headline "False memories prime our defences"




















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.









































































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If you are having a technical problem posting a comment, please contact technical support.








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Briton survived Outback by drinking contact lens fluid






SYDNEY: A British backpacker who endured three days missing in Australia's punishing Outback survived by drinking his contact lens fluid and urine, his mother said Sunday.

Samuel Woodhead, 18, was found Friday on the sprawling remote property Upshot Station, about 130 kilometres (80 miles) from the far-flung central Queensland town of Longreach, from where he had set off on Tuesday.

He became lost in extremely harsh terrain and mother Claire Derry credited his training at the Royal Military Academy Sandhurst for his survival in the remote and unforgiving Outback with little more than sunburn and dehydration.

"He tried drinking his own urine and he wasn't able to cope much with that, so he drank tiny sips of the contact lens fluid," Derry told the Sun-Herald newspaper.

He lost 15 kilograms over three days and nights and Derry said she and her son were both incredulous that he'd been found alive.

"Sam is incredibly fit, that was something I clung on to," she said, adding that her son wanted to go into the Royal Marines or the army.

"He'd not long ago been on an appropriateness course for Sandhurst... so I knew he had a lot of knowledge to draw on."

Australian authorities had held grave fears for the man's survival in a region where heat, a lack of water, venomous snakes and the possibility of injury could prove deadly.

Planes, motorbikes, and four-wheel drives were being used in the search, with neighbours also combing the area on foot and horseback and an emergency services helicopter dispatched with medical staff.

When he was found Derry said her son told her his rescuers said "they normally find people out here with their eyes pecked out.

"All he could say was 'Mum, just thank these wonderful people. I've loved Australia from the minute I arrived here. These people are extraordinary'."

Derry was on board a flight from Britain to Australia and had been fearing the worst when she learned that her son had been found alive. She celebrated by embracing the flight crew and popping some champagne.

"One of the airline staff came up to me and he was smiling. He handed me this piece of paper saying Sam was found alive and well," she said.

- AFP/ir



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Russian meteorite: The conspiracy theories



A strange time for a military attack?



(Credit:
CNN; screenshot by Chris Matyszczyk/CNET)


A good hearty conspiracy theory can shine a sharp light on two of humanity's most enduring traits.


One, of course, is humanity's boundless imagination. The other is humanity's essential suspicion of humanity.


So while you might be deeply immersed in Bill Nye's explanation of the Russian meteorite, those with darker sensibilities have filled the Web with their fears and hauntings about the phenomenon.


There are few nations with greater awareness of dark sensibilities than Russia. The fact that there seems to be little evidence of meteorite fragments on the ground has encouraged some Russians to offer their own suspicions.




As the Toronto Globe and Mail reports, nationalist leader Vladimir Zhirinovsky hasn't been slow to offer something of a Hot War perspective.

"It's not meteors falling. It's a new weapon being tested by the Americans," he was quoted as saying.


We know from our recent experience of North Korea that weapons testing is an imprecise science.


But if you were an American in the mood to test a weapon, would Chelyabinsk, Russia, be your very first choice of place for the experiment?


Perhaps Tallahassee; Area 51; and Bialystok, Poland, were all unavailable due to prior commitments. Or perhaps it wasn't the Americans, but, say, the North Koreans, who mistook Chelyabinsk for, say, Chelsea.


Zhirinovsky's rather emotionally manipulative offering was countered by Russia's Emergency Ministry, which dedicated itself to an extensive rebuttal of his belief (and that of others) that this was some sort of military thing. The rebuttal? "Rubbish."


But that wasn't going to put off the local media, was it? Not only do they have papers to sell, they also have theories to expound to a troubled nation and world.


So, as The Atlantic reports, the local Znak newspaper accepted that this was a meteorite but insisted the explosion was caused by military defense blowing it up.



More Technically Incorrect



Yes, of course it has a source in the military. You thought it didn't?


Though I've watched a few movies in which exciting things happen, I don't find it easy to imagine that some sort of terrestrially created missile-laden aircraft could really explode a meteorite in such a manner.


It is easier to imagine, though, that politicians like Zhirinovsky might take the opportunity to foment a little rage.


Indeed, Alex Jones' infamously well-guarded Infowars site offered that Zhirinovsky insisted that America -- in the person of Secretary of State John Kerry -- had tried to give Russia advance notice of its "attack."


The Drudge Report led me to a piece at Foreign Policy that explained that Sergey Lavrov, Russia's foreign minister, simply hadn't called Kerry back.


Which all suggests that Russia isn't, after all, living in fear of an attack from the U.S. Especially one over Chelyabinsk.


On balance, I prefer to currently believe Nye. He is the science guy, after all. And science guys know scientific events when they see them.


I hope.


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Picture Archive: Making Mount Rushmore, 1935-1941

Photograph from Rapid City Chamber of Commerce/National Geographic

There's no such thing as Presidents' Day.

According to United States federal government code, the holiday is named Washington's Birthday, and has been since it went nationwide in 1885.

But common practice is more inclusive. The holiday expanded to add in other U.S. presidents in the 1960s, and the moniker Presidents' Day became popular in the 1980s and stuck. It may be that George Washington (b. February 22, 1732) andAbraham Lincoln (b. February 12, 1809) still get the lion's share of attention—and appear in all the retail sale ads—on the third Monday in February, but the popular idea is that all 44 presidents get feted.

Mount Rushmore is a lot like that one day a year writ large—and in granite. It's carved 60 feet (18 meters) tall and 185 feet (56 meters) wide, from Washington's right ear to Lincoln's left.

The monument's sculptor, Gutzon Borglum, grew up in Idaho, a first-generation American born to Danish parents. He studied art in France and became good friends with Auguste Rodin. Borglum mostly worked in bronze, but in the early 1910s he was hired to carve the likenesses of Confederate leaders into Stone Mountain in Georgia.

He was about to be fired from that job for creative differences about the same time that a South Dakota historian named Doane Robinson had an idea. Robinson wanted to have a monument carved into the Black Hills of South Dakota, maybe Western historical figures like Chief Red Cloud and Lewis and Clark, each on their own granite spire. (Plan a road trip in the Black Hills.)

Robinson hired Borglum and gave him carte blanche. Borglum was looking for something with national appeal, so he chose to depict four presidents: George Washington, Thomas Jefferson, Theodore Roosevelt, and Abraham Lincoln.

Borglum wanted to represent the first 150 years of the nation's history, choosing four presidents as symbols of their respective time periods. He took a tour of western South Dakota, searching for an ideal canvas.

The sculptor was looking for three things: a surface strong enough to sculpt, a mountain big enough to hold several figures, and a mountain face that received morning sunlight. Mount Rushmore fit the bill and was already part of a national forest, so it was easy to set aside as a national memorial.

Work started in 1927. Calvin Coolidge attended the dedication ceremony. It took 14 years to finish the carving, conducted mostly in summertime because of the area's harsh winters.

There were approximately 30 workers on the mountain at any give time. In total about 400 had worked on it by the time the monument was finished. Though the project involved thousands of pounds of dynamite and perilous climbs, not a single person died during the work.

Borglum himself died of natural causes in 1941, though, just six months before the project was declared "closed as is" by Congress that Halloween. His son Lincoln—named for his father's favorite president—took over.

In the photo above, a worker refines the details of Washington's left nostril.

About 90 percent of the mountain was carved using dynamite, which could get within 3 to 5 inches (8 to 13 centimeters) of the final facial features. For those last few inches, workers used what was known as the honeycomb method: Jackhammer workers pounded a series of three-inch-deep holes followed up by chiselers who knocked off the honeycomb pieces to get the final shape. Then carvers smoothed the "skin's" surface.

—Johnna Rizzo

February 16, 2013

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Meteor Blast Creates Rush to Cash In












The shattered glass and broken walls caused by the massive explosion of a monstrous meteor over this remote, industrial Russian city is not even cleaned up, and people are already trying to cash in.


Some residents want to turn this city known mostly for its tank factory into a tourist destination, while others from all around the world are determined to find fragments of the meteorite.


Meteor hunters say it's a once in a lifetime opportunity. A small piece of the space rock that exploded over Russia Friday could be worth thousands of dollars, and bigger chunks could fetch hundreds of thousands.


SEE PHOTOS: Meteorite Crashes in Russia


"I haven't been able to sleep for the last two days because of this," said Michael Farmer, who runs the website Meteor Hunter. "This is a once in a lifetime event. We've never seen anything like this in the last hundred years."


He said he started planning a trip to Chelyabinsk as soon as the meteorite exploded.


"The next morning I was on the phone working on visas. I'd like to get a visa and get over to Russia as quickly as possible," he said. "When this type of thing happens, you know hours count so we try to arrange that as fast as possible."


A day after a massive meteor exploded over this city in central Russia, a monumental cleanup effort is under way.


Authorities have deployed around 24,000 troops and emergencies responders to help in the effort.


Officials say more than a million square feet of windows -- the size of about 20 football fields -- were shattered by the shockwave from the meteor's blast. Around 4,000 buildings in the area were damaged.






Nasha gazeta, www.ng.kz/AP Photo













The injury toll climbed steadily on Friday. Authorities said today it now stands at more than 1,200. Most of those injuries were from broken glass, and only a few hundred required hospitalization.


According to NASA, this was the biggest meteor to hit Earth in more than a century. Preliminary figures suggest it was 50 feet wide and weighed more than the Eiffel Tower.


NASA scientists have also estimated the force of the blast that occurred when the meteor fractured upon entering Earth's atmosphere was approximately 470 kilotons -- the equivalent of about 30 Hiroshima bombs, but it did not cause major damage because it occurred so high in the atmosphere.


"This was caused by a small asteroid, about 15 meters in diameter, coming in at around 18 kilometers per second, that's in excess of 40-thousand miles per hour," NASA planetary scientist Paul Abell said. "As the asteroid comes in, it interacts with the atmosphere and effectively it converts all the energy, the kinetic energy of the asteroid, the mass of the asteroid and the velocity and it's actually that velocity, the asteroid just effectively explodes and that creates the pressure wave, the blast wave that comes down."


Treasure hunters hoping to cash in on the bits of space rock aren't the only ones eager to find pieces of the meteor, Abell said. Scientists say the material could offer valuable information.


"One of the things we'd like to learn is first of all, what was the composition of the asteroid, where did it come from," he said. "We know it came from the asteroid belt but can we link it to a bigger asteroid and also, get an idea of the dispersal pattern."


Residents said they still can't believe it happened here.


"It was something we only saw in the movies," one university student said. "We never thought we would see it ourselves."


Throughout the city, the streets are littered with broken glass. Local officials have announced an ambitious pledge to replace all the broken windows within a week. In the early morning hours, however, workers could still be heard drilling new windows into place.


Authorities have sent divers into a frozen lake outside the city, where a large chunk of the meteor is believed to have landed, creating a large hole in the ice. By the end of the day they had not found anything.



Read More..

False memories prime immune system for future attacks









































IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.












When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.












Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.












The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.












The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."












So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.












To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).












The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.












"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"












This article appeared in print under the headline "False memories prime our defences"




















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.


If you are having a technical problem posting a comment, please contact technical support.








Read More..

Anti-North Korea leaflets launched on Kim's birthday






IMJINGAK, South Korea: North Korean defectors in the South launched 200,000 anti-Pyongyang leaflets across the tense inter-Korean border on Saturday, the birth anniversary of the North's late leader Kim Jong-Il.

The defectors used gas-filled balloons to float the leaflets along with $1 currency notes across the western border town of Imjingak, despite high tensions owing to the North's third nuclear test on Tuesday.

The balloons were inscribed with slogans such as "Stop provocative acts with missiles and nuclear tests", "North Koreans rise up" and "The Kim dynasty will soon collapse".

North Korea celebrates the birthdays of both late leaders -- Kim Jong-Il's on February 16 and his father Kim Il-Sung's on April 15 -- as major national holidays.

Kim Jong-Il, who died of heart attack in December 2011, was succeeded by his son Jong-Un.

Anti-Pyongyang activists momentarily suspended such leaflet launches until after the South's presidential election in December as the government urged them to halt such activities for fear of provoking Pyongyang.

North Korea has in the past threatened "merciless military strike" in response to anti-regime propaganda leaflets, with local residents warned to evacuate such areas.

The North conducted a third nuclear test on Tuesday, whose detonation power was much larger than those of two previous ones in 2006 and 2009.

Pyongyang said the test was a riposte to UN sanctions imposed after its launch of a long-range rocket in December, which it claimed was part of a legitimate space programme.

- AFP/ck



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E-orders for 128GB Surface Pro to ship in 2-3 weeks -- Microsoft




Microsoft provided another update at the end of this week regarding the availability of its sold-out 128GB version of the Surface Pro.


A February 15 Surface Blog post said that those ordering through the Microsoft online store in the U.S. can place an order for the 128GB model and have it ship in two to three weeks.


The new post also provided updated information for those wanting to "reserve" the Intel-based PC/tablet hybrid
Surface Pro devices. Up until now, Microsoft officials have declined comment when asked whether users would be able to pre-order Surface Pros.


Here's the latest Surface Pro availability guidance:




At Best Buy (U.S.): Inventory levels are increasing and many Best Buy stores have Surface Pro units for sale in-store. If the store does not have stock, you can reserve a Surface Pro (64GB and 128GB). Please note that Best Buy is only taking reservations in their stores for Surface Pro based on new inventory they know is coming in next week, so it's possible that reservations could become "sold out."


At Staples (U.S.): Many Staples stores have Surface Pro units for sale in stores. If the store does not have stock, you can place a kiosk order in store to purchase Surface Pro 64GB for delivery.


For Canada: In Best Buy and Future Shop stores you can reserve the 64GB Surface Pro in stores at this time. Staples has availability online while inventory lasts and more inventory has been ordered to ensure store availability in the near future. More details to come on the 128GB Surface Pro availability in Canada.




It seems that Staples is making the 128GB Surface Pros available for order online and that they are not being stocked in Staples brick-and-mortar outlets, as I noted earlier this week.


Microsoft is "work(ing) around the clock to meet that demand with production and get new inventory into retail," the post concluded. Company officials advise customers interested in the Pros to call ahead before venturing to stores this weekend, in spite of guidance earlier in the week that more stores would have stock on hand starting on Saturday, February 16.


It's still unclear why there are not enough Surface Pros on the market. Is it that Microsoft seriously underestimated demand for 128GB Surface Pros -- a happy problem for the Softies? Or have supply-chain problems led to device shortages (a not-so-happy problem)? Microsoft's Surface Pro devices went on sale February 9.


This story originally appeared on ZDNet under the headline "Microsoft: Online orders for 128 GB Surface Pro to ship in two to three weeks."


Read More..

Why the Dog Show Winner Looks Like a Monkey


Standing less than a foot tall and easily cradled in one of trainer Ernesto Lara's arms, Banana Joe made big news for a small dog when he became the first affenpinscher to win the Westminster Kennel Club dog show on Tuesday.

His short stature and flattened face might not make Banana Joe look like a typical winner: The name "affenpinscher" is German for "monkey terrier," and its mug is definitely simian in appearance. Now this lesser known breed is basking in the spotlight, monkey face and all. (Read "How to Build a Dog" in National Geographic magazine.)

Why the Flat Face?

People like dogs whose faces kind of look like people, with a squished-in nose and forward-facing eyes: Pekinese, bullmastiffs, and affenpinschers, to name a few. "It's mimicking the way humans appear," said Jeffrey Schoenebeck, a research fellow at the National Institutes of Health who has analyzed the development of shortened canine snouts. Several centuries ago, breeders probably sought out parents with a flat face. (Genetics note: Gene BMP3 likely contributes to a flat face in toy breeds.)

And so Banana Joe's mug reflects centuries of genetic manipulation. There's no advantage for the dog, Schoenebeck notes, except that humans would crave it more as a companion. (Related: Gallery of Dog Pictures.)

What About That Tongue?

Banana Joe sticks out his little pink tongue a lot. Maybe more than your run-of-the-mill canine. The reason may be the flat face. "There's probably less room in their mouth" for the tongue, said Schoenebeck. "It's hanging out."

Why so Small?

"The Affenpinscher comes from a terrier background," explained NIH senior staff scientist Heidi Parker, and like all terriers, it was bred to chase. The early affenpinschers' specialty was hunting down rats and other vermin for its owners. Breeding for a small size came later, as ladies started bringing affenpinschers into the home as lap dogs-and to keep away vermin that might otherwise hide in corners or under long skirts. Today's affenpinschers are in the 6-to-13 pound (3-to-6 kilogram) range.

But the dog's size hasn't given it an inferiority complex. "Most of these little guys do not realize they're as small as they are," Parker says. Toy dogs have been known to chase birds and other animals that rival them in size.

What Comes After Westminster?

Dog lovers may crave an affenpinscher. And that could cause problems if breeders try to produce more pups.

"You'll see some breeds go through sudden explosions, where they'll go from small numbers to really large numbers," says Parker. "Usually that means an increase in genetic diseases." There aren't a lot of potential parents for a purebred litter, so the odds of inbreeding, and its related diseases, go up.

And What About Banana Joe?

Now that he's made us aware of his breed, Banana Joe will retire from competition and live with his Dutch owner, free to fulfill his heritage as a lap dog.


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Carnival Cruise Ship Hit With First Lawsuit












The first lawsuit against Carnival Cruise Lines has been filed and it is expected to be the beginning of a wave of lawsuits against the ship's owners.


Cassie Terry, 25, of Brazoria County, Texas, filed a lawsuit today in Miami federal court, calling the disabled Triumph cruise ship "a floating hell."


"Plaintiff was forced to endure unbearable and horrendous odors on the filthy and disabled vessel, and wade through human feces in order to reach food lines where the wait was counted in hours, only to receive rations of spoiled food," according to the lawsuit, obtained by ABCNews.com. "Plaintiff was forced to subsist for days in a floating toilet, a floating Petri dish, a floating hell."


Click Here for Photos of the Stranded Ship at Sea


The filing also said that during the "horrifying and excruciating tow back to the United States," the ship tilted several times "causing human waste to spill out of non-functioning toilets, flood across the vessel's floors and halls, and drip down the vessel's walls."


Terry's attorney Brent Allison told ABCNews.com that Terry knew she wanted to sue before she even got off the boat. When she was able to reach her husband, she told her husband and he contacted the attorneys.


Allison said Terry is thankful to be home with her husband, but is not feeling well and is going to a doctor.








Carnival's Triumph Passengers: 'We Were Homeless' Watch Video









Girl Disembarks Cruise Ship, Kisses the Ground Watch Video









Carnival Cruise Ship Passengers Line Up for Food Watch Video





"She's nauseated and actually has a fever," Allison said.


Terry is suing for breach of maritime contract, negligence, negligent misrepresentation and fraud as a result of the "unseaworthy, unsafe, unsanitary, and generally despicable conditions" on the crippled cruise ship.


"Plaintiff feared for her life and safety, under constant threat of contracting serious illness by the raw sewage filling the vessel, and suffering actual or some bodily injury," the lawsuit says.


Despite having their feet back on solid ground and making their way home, many passengers from the cruise ship are still fuming over their five days of squalor on the stricken ship and the cruise ship company is likely to be hit with a wave of lawsuits.


"I think people are going to file suits and rightly so," maritime trial attorney John Hickey told ABCNews.com. "I think, frankly, that the conduct of Carnival has been outrageous from the get-go."


Hickey, a Miami-based attorney, said his firm has already received "quite a few" inquiries from passengers who just got off the ship early this morning.


"What you have here is a) negligence on the part of Carnival and b) you have them, the passengers, being exposed to the risk of actual physical injury," Hickey said.


The attorney said that whether passengers can recover monetary compensation will depend on maritime law and the 15-pages of legal "gobbledygook," as Hickey described it, that passengers signed before boarding, but "nobody really agrees to."


One of the ticket conditions is that class action lawsuits are not allowed, but Hickey said there is a possibility that could be voided when all the conditions of the situation are taken into account.


One of the passengers already thinking about legal action is Tammy Hilley, a mother of two, who was on a girl's getaway with her two friends when a fire in the ship's engine room disabled the vessel's propulsion system and knocked out most of its power.


"I think that's a direction that our families will talk about, consider and see what's right for us," Hilley told "Good Morning America" when asked if she would be seeking legal action.






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