Crave Ep. 110: Prevent a hangover with the worlds first 'sober pill'?



Prevent a hangover with the worlds first 'sober pill'? Ep 110



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Cheers! Scientists have created what may be the world's first pill that can make you sober if you've gone a little too far with the booze. Russian meteorite fragments go up for sale on online, as do Milla Jovovich's shorts. And later this year a man will have surgery to attach a bionic hand that can feel touch sensations.




Crave stories:


- Russian meteorite fragments pop up for sale online

- Amazon opens celebrity memorabilia store

- Nanotech 'sober pill' could one day de-drunk you

- This sheet turns your windows into mirrors

- Man to get first bionic hand that can 'feel'

- Sony PS4 event skewered in animated parody


- Crave giveaway! Kanex Sydnee four-port recharging station

Social networking:

- Stephen on Twitter

- Stephen on Google+


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Cyberattacks Bring Attention to Security Reform











Recent accusations of a large-scale cyber crime effort by the Chinese government left many wondering what immediate steps the president and Congress are taking to prevent these attacks from happening again.


On Wednesday, the White House released the administration's Strategy on Mitigating the Theft of U.S. Trade Secrets as a follow-up to the president's executive order. The strategy did not outwardly mention China, but it implied U.S. government awareness of the problem.


"We are taking a whole of government approach to stop the theft of trade secrets by foreign competitors or foreign governments by any means -- cyber or otherwise," U.S. Intellectual Property Enforcement Coordinator Victoria Espinel said in a White House statement.


As of now, the administration's strategy is the first direct step in addressing cybersecurity, but in order for change to happen Congress needs to be involved. So far, the Cyber Intelligence Sharing and Protection Act (CISPA) is the most notable Congressional legislation addressing the problem, despite its past controversy.


Last April, CISPA was introduced by House Intelligence Committee Chairman Mike Rogers, R-Mich., and Rep. Dutch Ruppersberger, D-Md. The act would allow private companies with consumer information to voluntarily share those details with the NSA and the DOD in order to combat cyber attacks.






Peter Parks/AFP/Getty Images







The companies would be protected from any liabilities if the information was somehow mishandled. This portion of the act sounded alarm bells for CISPA's opponents, like the ACLU, which worried that this provision would incentivize companies to share individuals' information with disregard.


CISPA passed in the House of Representatives, despite a veto threat from the White House stemming from similar privacy concerns. The bill then died in the Senate.


This year, CISPA was reintroduced the day after the State of the Union address during which the president declared an executive order targeting similar security concerns from a government standpoint.


In contrast to CISPA, the executive order would be initiated on the end of the government, and federal agencies would share relevant information regarding threats with private industries, rather than asking businesses to supply data details. All information shared by the government would be unclassified.


At the core of both the executive order and CISPA, U.S. businesses and the government would be encouraged to work together to combat cyber threats. However, each option would clearly take a different route to collaboration. The difference seems minimal, but has been the subject of legislative debates between the president and Congress for almost a year, until now.


"My response to the president's executive order is very positive," Ruppersberger told ABC News. "[The president] brought up how important information sharing is [and] by addressing critical infrastructure, he took care of another hurdle that we do not have to deal with."


Addressing privacy roadblocks, CISPA backers said the sharing of private customer information with the government, as long as personal details are stripped, is not unprecedented.


"Think of what we do with HIPAA in the medical professions; [doctors do not need to know] the individual person, just the symptoms to diagnose a disease," Michigan Gov. John Engler testified at a House Intelligence Committee hearing in an attempt to put the problem into context.






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Synthetic llama antibodies soothe arthritis pain


































ARTHRITIS may have met its match, in the form of the llama immune system. Antibodies similar to ones originally discovered in camels and llamas have helped to heal moderate to severe arthritis in a small trial.













The antibodies have inspired the design of a drug, ALX-0061, that blocks a receptor for interleukin 6. This signalling molecule amplifies inflammation, leading to sore and swollen joints. The symptoms ease once the receptor is blocked.











In the trial, 24 patients received one of three unchanging doses of ALX-0061 for six months. Another group received a placebo. Sixty-three per cent of those given the drug saw their symptoms practically vanish when measured using a standard metric, the DAS28 scale, which evaluates symptoms in 28 joints. This figure is more than twice the 30 per cent remission rate seen with the current "gold-standard" rival treatment Actemra (tocilizumab). Tocilizumab also targets interleukin 6, but it is based on a normal-sized mammalian antibody.













The remission rate was even higher – 75 per cent – for the eight patients given one of the three doses: 3 milligrams per kilogram of body weight administered once every four weeks. "These data suggest that out of every 10 patients, seven to eight could experience rapid, durable responses to their symptoms," says Josi Holz, the chief medical officer of Ablynx, in Ghent, Belgium, which released its results on 13 February.












According to Ed Moses, CEO of Ablynx, it could be the tiny size of the molecule – one-fifth the usual size – that gives it the edge over existing antibody-based treatments. "It potentially gives far faster and deeper penetration of diseased joints," he says.












Other researchers caution against over-optimism because the trial was short and small. "If the results are repeated in randomised, controlled, double-blinded studies, then they would be very impressive," says David Scott, chief medical adviser to the UK's National Rheumatoid Arthritis Society.












To take ALX-0061 forward, Ablynx is now looking for a partner to help finance such a larger, decisive trial.












This article appeared in print under the headline "Llama-inspired drug relieves arthritic pain"




















































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Locals fill most jobs at new plant on Jurong Island






SINGAPORE: Tuas Power's Tembusu multi-utilities complex on Jurong Island has generated 150 jobs ahead of its official opening next week.

One hundred positions have been filled and the plant's looking for Singaporeans to fill 50 more vacancies.

Nine in 10 positions are currently held by locals.

The jobs are technical in nature, with Tuas Power looking out for graduates from polytechnics and the Institutes of Technical Education.

The Jurong Island facility provides steam, water and electricity to petrochemical firms.

Phase one of the plant's operations has been completed, with full completion expected no later than 2017.

By then, the plant would have generated a total of some 200 jobs.

- CNA/ck



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Conan can't resist making an ass of Google Glass



Asstounding?



(Credit:
Conan Screenshot by Chris Matyszczyk/CNET)


When it comes to late-night talk shows, I am not sure if Conan O'Brien is bringing up the rear.


He seems, though, to be keen on suggesting that
Google Glass might be scraping the bottom of the barrel.


It's not so much that Google has created these new glasses through which you can have a richer, more informative view of the world. It's that the company has created a sister device, intended to be worn as, well, a back-up.


And so we see Google Glass from the other side of life. It is the side most familiar to dogs and bicycle seats.


You must decide whether you find Conan's revelation -- or, indeed, Conan himself -- funny.


But such humor serves to offer that Google's funny little glasses are having a small impact on the outside world.


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Oldest Known Wild Bird Hatches Chick at 62



Wisdom, the oldest known wild bird, has yet another feather in her cap—a new chick.


The Laysan albatross (Phoebastria immutabilis)—62 years old at least—recently hatched a healthy baby in the U.S. Midway Atoll National Wildlife Refuge, her sixth in a row and possibly the 35th of her lifetime, according to the U.S. Geological Survey's (USGS) North American Bird Banding Program. (Related: "51-Year-Old Albatross Breaks N. American Age Record [2003].")


But Wisdom's longevity would be unknown if it weren't for a longtime bird-banding project founded by USGS research wildlife biologist Chandler Robbins.


Now 94, Robbins was the first scientist to band Wisdom in 1956, who at the time was "just another nesting bird," he said. Over the next ten years, Robbins banded tens of thousands of black-footed albatrosses (Phoebastria nigripes) and Laysan albatrosses as part of a project to study the behavior of the large seabirds, which at the time were colliding with U.S. Navy aircraft.


Robbins didn't return to the tiny Pacific island—now part of the U.S. Papahānaumokuākea Marine National Monument—until 2002, when he "recaptured as many birds as I could in hopes that some of them would be the old-timers."


Indeed, Robbins did recapture Wisdom—but he didn't know it until he got back to his office at the Patuxent Wildlife Research Center in Laurel, Maryland, and checked her band number in the database.


"That was real exciting, because we didn't think the chances of finding one that old would be that good," Robbins said Wednesday in an interview from his office at the Patuxent center, where he still works.



Chandler Robbins counts birds.

Chandler Robbins counts birds in Maryland's Patuxent Research Refuge.


Photograph by David H. Wells, Corbis




Albatrosses No Bird Brains


Bigger birds such as the albatross generally live longer than smaller ones: The oldest bird in the Guinness Book of Animal Records, a Siberian white crane (Leucogeranus leucogeranus), lived an unconfirmed 82 years. Captive parrots are known to live into their 80s. (See National Geographic's bird pictures.)



The Laysan albatross spends most of the year at sea, nesting on the Midway Atoll (map) in the colder months. Birds start nesting around five years of age, which is how scientists knew that Wisdom was at least five years old in 1956.



Because albatrosses defend their nests, banding them doesn't require a net or a trap as in the case of other bird species, Robbins said—but they're far from tame.


"They've got a long, sharp bill and long, sharp claws—they could do a job on you if you're not careful how to handle them," said Robbins, who estimates he's banded a hundred thousand birds.


For instance, "when you're not looking, the black-footed albatross will sneak up from behind and bite you in the seat of the pants."


But Robbins has a fondness for albatrosses, and Wisdom in particular, especially considering the new dangers that these birds face.


Navy planes are no longer a problem—albatross nesting dunes were moved farther from the runway—but the birds can ingest floating bits of plastic that now inundate parts of the Pacific, get hooked in longlines meant for fish, and be poisoned by lead paint that's still on some of Midway Atoll's buildings. (Also see "Birds in 'Big Trouble' Due to Drugs, Fishing, More.")


That Wisdom survived so many years avoiding all those hazards and is still raising young is quite extraordinary, Robbins said.


"Those birds have a tremendous amount of knowledge in their little skulls."


"Simply Incredible"


Wisdom's accomplishments have caught the attention of other scientists, in particular Sylvia Earle, an oceanographer and National Geographic Explorer in Residence, who said by email that Wisdom is a "symbol of hope for the ocean." (National Geographic News is part of the National Geographic Society.)


Earle visited Wisdom at her nest in January 2012, where she "appeared serenely indifferent to our presence," Earle wrote in the fall 2012 issue of the Virginia Quarterly Review.


"I marveled at the perils she had survived during six decades, including the first ten or so years before she found a lifetime mate. She learned to fly and navigate over thousands of miles to secure enough small fish and squid to sustain herself, and every other year or so, find her way back to the tiny island and small patch of grass where a voraciously hungry chick waited for special delivery meals."


Indeed, Wisdom has logged an estimated two to three million miles since 1956—or four to six trips from Earth to the moon and back, according to the USGS. (Related: "Albatross's Effortless Flight Decoded—May Influence Future Planes.")


Bruce Peterjohn, chief of the North American Bird Banding Program, called Wisdom's story "simply incredible."


"If she were human, she would be eligible for Medicare in a couple years—yet she is still regularly raising young and annually circumnavigating the Pacific Ocean," he said in a statement.


Bird's-Eye View


As for Robbins, he said he'd "love to get out to Midway again." But in the meantime, he's busy going through thousands of bird records in an effort to trace their life histories.


There's much more to learn: For instance, no one has ever succeeded in putting a radio transmitter on an albatross to follow it throughout its entire life-span, Robbins noted.


"It would be [an] exciting project for someone to undertake, but I'm 94 years old," he said, chuckling. "It wouldn't do much for me to start a project at my age."


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Arias Challenged On Pedophilia Claim












Accused murderer Jodi Arias was challenged today by phone records, text message records, and her own diary entries that appeared to contradict her claim that she caught her ex-boyfriend, Travis Alexander, looking at pictures of naked boys.


Arias had said during her testimony that one afternoon in January 2008, she walked in on Alexander masturbating to pictures of naked boys. She said she fled from the home, threw up, drove around aimlessly, and ignored numerous phone calls from Alexander because she was so upset at what she had seen.


The claim was central to the defense's accusation that Alexander was a "sexual deviant" who grew angry and abusive toward Arias in the months after the incident, culminating in a violent confrontation in June that left Alexander dead.


Arias claimed she killed him in self-defense. She could face the death penalty if convicted of murder.


Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage


Today, prosecutor Juan Martinez, who has been aggressive in questioning witnesses throughout the trial, volleyed questions at her about the claim of pedophilia, asking her to explain why her and Alexander's cell phone records showed five calls back and forth between the pair throughout the day she allegedly fled in horror. Some of the calls were often initiated Arias, according to phone records.








Jodi Arias Doesn't Remember Stabbing Ex-Boyfriend Watch Video









Jodi Arias Murder Trial: Testimony About Ex's Death Watch Video









Arias on Ex-Boyfriend's Death: 'I Don't Remember' Watch Video





She and Alexander also exchanged text messages throughout the afternoon and evening at a time when Arias claims the pedophilia incident occurred. In those messages they discuss logistics of exchanging one another's cars that night. Alexander sends her text messages about the car from a church social event he attended that night that she never mentioned during her testimony.


Arias stuck by her claim that she saw Alexander masturbating to the pictures, and her voice remained steady under increasingly-loud questioning by Martinez.


But Martinez also sparred with Arias on the stand over minor issues, such as when he asked Arias detailed questions about the timing and order of events from that day and Arias said she could not remember them.


"It seems you have problems with your memory. Is this a longstanding thing? Since you started testifying?" Martinez asked.


"No it goes back farther than that. I don't know even know if I'd call it a problem," Arias said.


"How far back does it go? You don't want to call them problems, are they issues? Can we call them issues? When did you start having them?" he asked in rapid succession. "You say you have memory problems, that it depends on the circumstance. Give me the factors that influence that."


"Usually when men like you or Travis are screaming at me," Arias shot back from the stand. "It affects my brain, it makes my brain scramble."


"You're saying it's Mr. Martinez's fault?" Martinez asked, referring to himself in the third person.


"Objection your honor," Arias' attorney finally shouted. "This is a stunt!"


Timeline of the Jodi Arias Trial


Martinez dwelled at one point about a journal entry where Arias wrote that she missed the Mormon baptism of her friend Lonnie because she was having kinky sex with Alexander. He drew attention to prior testimony that she and Alexander used Tootsie Pops and Pop Rocks candy as sexual props.


"You're trying to get across (in the diary entry) that this involved a sexual liaison with Mr. Alexander right?" he asked. "And you're talking about Tootsie Pops and Pop Rocks?"


"That happened also that night," Arias said.


"You were there, enjoying it, the Tootsie Pops and Pop Rocks?" he asked again, prompting a smirk from Arias.


"I enjoyed his attention," Arias said.






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Tobacco giant wants to help you quit smoking






















British American Tobacco aims to turn electronic cigarettes into medicines in the UK. It's a welcome move, but leaves a bitter taste in the mouth
















BACK in the 1950s, when the dangers of smoking were becoming clear and the tobacco industry was panicked, cigarette-makers came up with a wheeze: safer smokes. Filter-tipped, low-tar and "light" cigarettes were the result.












In reality, those cigarettes were not safer at all. Smokers inhaled more deeply or smoked more. And the industry knew it. Internal documents later revealed that they cynically promoted safer cigarettes to discourage people from quitting.











Given this history of smoke and mirrors, you could be forgiven for being suspicious when a tobacco company announces that it is investing in a "reduced risk" cigarette. In December, British American Tobacco (BAT) bought a company called CN Creative, which makes "electronic cigarettes". It is now planning to ask the UK authorities to recognise one of its products as a smoking-cessation medicine.


















History repeating? Probably not. You could argue that aiming to profit from curing an addiction that you helped cause in the first place is pretty cynical. But credit where it is due: BAT and other tobacco companies now openly admit that smoking is a serious health risk. There is mounting evidence that e-cigarettes are safer than smoking and really can help addicts cut down or quit. They seem especially useful for hard-core smokers who have failed to quit or who don't even want to try (see "E-cigarettes may soon be sold as life-saving medicine").













There are still unanswered scientific questions, including how e-cigarettes compare with existing medicines such as nicotine patches. That will form a big part of the debate on whether to license them as a medicine.












Long-term safety is also open to question, as is whether they will serve as a "gateway" product attracting new people to smoking, and if their use in public places will renormalise smoking at a time when it is increasingly frowned upon.












But again, the evidence is pointing in the right direction. Tellingly, the anti-tobacco group Action on Smoking and Health has given a qualified backing to e-cigarettes for harm reduction. ASH sensibly points out that e-cigarettes are clearly safer than inhaling tobacco smoke, and says there is little evidence that they will attract non-smokers or make smoking acceptable again. If so, there is little reason to worry about unintended consequences.











Don't hold your breath, though. A similar argument has been made for "snus", a form of oral tobacco mainly used in Sweden. There is evidence that it can help smokers quit and that it is safer than smoking. Sweden has the lowest rates of smoking and lung cancer in Europe, which is often attributed to the use of snus. By some estimates, if Sweden's snus habit was replicated across the European Union it would prevent 92,000 lung cancer deaths a year (Scandinavian Journal of Public Health, vol 37, p 481). And yet it remains illegal everywhere in the EU but Sweden, condemned as a carcinogen and a potential gateway to smoking. The lesson? Harm reduction is a tough sell.













It may be distasteful to watch a tobacco company spearhead a campaign for cigarette harm reduction. But action is sorely needed. If the evidence stacks up, they should be given the benefit of the doubt – for now.


















































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Australia's Fairfax up on asset sales; revenues plunge






SYDNEY: Ailing Australian media company Fairfax on Thursday unveiled a quadrupling of first-half profit to A$386.3 million (US$395.5 million) after offloading assets to guard against plunging revenues.

Fairfax, publisher of The Age and Sydney Morning Herald broadsheets and owner of radio and digital assets, said net profit for the half-year to December 31 was almost four times that of the Aus$96.7 million over the same period last year.

The profit surge was underpinned by over A$300 million in one-off gains including from the sale of a stake in major New Zealand online auction site TradeMe and United States agricultural publishing business Penton Media Inc.

Revenue continued to bleed, down 7.1 percent on the previous corresponding period, as advertisers and readers turned to other sources, but Fairfax said it had paid down some A$717 million of its debt, reducing it to A$197 million.

Underlying earnings excluding significant items slumped 22.2 percent to A$230.3 million, in line with market expectations.

"For some time we have considered it prudent to manage Fairfax Media on the basis that a significant cyclical upswing was unlikely in the near term," said CEO Greg Hywood.

"While the economic environment continues to be stressed and structural change presents (an) ongoing challenge our overall performance is in line with expectations. Our transformation is ahead of schedule."

Fairfax sent shockwaves through Australia's media sector in June by announcing it would sack 1,900 staff and put its newspapers - the only serious rival to Rupert Murdoch's vast Australian holdings - behind a paywall.

Its shares hit an all-time low in August after staggering losses of A$2.73 billion due to massive writedowns in the value of mastheads and trade names.

As well as putting content behind a paywall, Fairfax has announced it will switch to tabloid format in a bid to save money and stave off advances from the likes of mining magnate Gina Rinehart, a major shareholder.

The latest circulation data, published last week, showed a steep decline for Fairfax titles, with the Sun Herald down 23 percent in the three months to December 31 when compared with the same period last year.

The Sunday Age was down 14 percent, the Saturday editions of both newspapers lost more than 13 percent and weekday editions plunged 14.5 percent in the quarter according to the Audit Bureau of Circulations.

- AFP/de



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