Local furniture makers urged to adopt green practices






SINGAPORE: More furniture manufacturers in Singapore will be encouraged to adopt green practices with the aim of being awarded green certifications.

This is part of a three-year plan by the Singapore Furniture Industries Council (SFIC) and Singapore Environment Council (SEC) with the signing of a Memorandum of Understanding (MOU).

To date, 11 SFIC members have been awarded green certificates by local and international bodies. The SFIC aims to double this number by 2014.

Under the MOU, SFIC and SEC will work together to improve furniture manufacturers' expertise in environmental sustainability.

This will be done through various programmes like training seminars and conferences.

There will be programmes to help companies undertake the SEC's Singapore Green Labelling Scheme (SGLS), a leading environmental standard and certification mark.

President of SFIC, Mr Ernie Koh, said, "Our Singapore furniture companies are already well-recognised in the global market for their high quality and professional business management. This MOU will further enhance our standing and raise our competitiveness and reputation in the eco-friendly furniture market."

- CNA/fa



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Microsoft moves Outlook.com out of preview




Microsoft announced Tuesday that its Outlook.com browser-based e-mail service has moved out of its preview stage and is now available globally.



First introduced last July, Outlook.com is Microsoft's boldest e-mail move since Google launched Gmail in 2004 and a clear answer to it. As I said in my First Take, the simple interface, Skydrive integration, and promise of mega storage will remind you of Google's product while the People Hub and vaguely Windows 8 look and feel give Outlook.com a distinct identity.




Microsoft designed Outlook.com to replace its Hotmail product, which it acquired in 1997, and the general availability marks the start of that process. The Hotmail name won't disappear entirely, but Outlook.com will become Microsoft's sole free consumer e-mail offering.



In a phone interview last week, Senior Director of Product Management Dharmesh Mehta said existing Hotmail users can switch over at anytime. You'll be able to keep using your "@Hotmail" address and you'll have the option to claim an "@Outlook.com" alias, as well.



Users who don't switch over on their own will be upgraded in waves to the new product automatically starting this week. Mehta said that the process should finish by the summer, though he declined to name an exact date.



Microsoft also announced that in the six months since Outlook.com debut, the service has attracted to 60 million users. And in an effort to attract more, Mehta said that the company is launching its largest marketing ever for an e-mail service.



Outlook.com's minimalist interface is both familiar and unique.



(Credit:
Screenshot by Kent German/CNET)


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Confirmed: Dogs Sneak Food When People Aren't Looking


Many dog owners will swear their pups are up to something when out of view of watchful eyes. Shoes go missing, couches have mysterious teeth marks, and food disappears. They seem to disregard the word "no."

Now, a new study suggests dogs might understand people even better than we thought. (Related: "Animal Minds.")

The research shows that domestic dogs, when told not to snatch a piece of food, are more likely to disobey the command in a dark room than in a lit room.

This suggests that man's best friend is capable of understanding a human's point of view, said study leader Juliane Kaminski, a psychologist at the U.K.'s University of Portmouth.

"The one thing we can say is that dogs really have specialized skills in reading human communication," she said. "This is special in dogs." (Read "How to Build a Dog.")

Sneaky Canines

Kaminski and colleagues recruited 84 dogs, all of which were more than a year old, motivated by food, and comfortable with both strangers and dark rooms.

The team then set up experiments in which a person commanded a dog not to take a piece of food on the floor and repeated the commands in a room with different lighting scenarios ranging from fully lit to fully dark.

They found that the dogs were four times as likely to steal the food—and steal it more quickly—when the room was dark. (Take our dog quiz.)

"We were thinking what affected the dog was whether they saw the human, but seeing the human or not didn't affect the behavior," said Kaminski, whose study was published recently in the journal Animal Cognition.

Instead, she said, the dog's behavior depended on whether the food was in the light or not, suggesting that the dog made its decision based on whether the human could see them approaching the food.

"In a general sense, [Kaminski] and other researchers are interested in whether the dog has a theory of mind," said Alexandra Horowitz, head of the Dog Cognition Lab at Barnard University, who was not involved in the new study.

Something that all normal adult humans have, theory of mind is "an understanding that others have different perspective, knowledge, feelings than we do," said Horowitz, also the author of Inside of a Dog.

Smarter Than We Think

While research has previously been focused on our closer relatives—chimpanzees and bonobos—interest in dog cognition is increasing, thanks in part to owners wanting to know what their dogs are thinking. (Pictures: How smart are these animals?)

"The study of dog cognition suddenly began about 15 years ago," Horowitz said.

Part of the reason for that, said Brian Hare, director of the Duke Canine Cognition Lab and author of The Genius of Dogs, is that "science thought dogs were unremarkable."

But "dogs have a genius—years ago we didn't know what that was," said Hare, who was not involved in the new research. (See pictures of the the evolution of dogs, from wolf to woof.)

Many of the new dog studies are variations on research done with chimpanzees, bonobos, and even young children. Animal-cognition researchers are looking into dogs' ability to imitate, solve problems, or navigate social environments.

So just how much does your dog understand? It's much more than you—and science—probably thought.

Selectively bred as companions for thousands of years, dogs are especially attuned to human emotions—and, study leader Kaminski said, are better at reading human cues than even our closest mammalian relatives.

"There has been a physiological change in dogs because of domestication," Duke's Hare added. "Dogs want to bond with us in ways other species don't." (Related: "Dogs' Brains Reorganized by Breeding.")

While research reveals more and more insight into the minds of our furry best friends, Kaminski said, "We still don't know just how smart they are."


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Russian Meteor: Close Encounter, Preventing Impacts





Feb 18, 2013 7:03pm



MOSCOW — As if Friday’s massive meteor explosion over central Russia weren’t enough, just hours later a large asteroid buzzed dangerously close to Earth.


And that evening, the California sky was lit up by a fireball, apparently entering Earth’s atmosphere.


It’s a barrage from space that has people asking: Are we ready for the big one?


Nearly 100 tons of space debris enters Earth’s atmosphere every day. Most of it burns up or falls harmlessly into the ocean, but experts still worry that eventually something big will come our way.


PHOTOS: Meteorite Crashes in Russia


epa russia meteor Chebarkul lake jt 130217 wblog Russian Meteor: Close Encounters and Plans to Prevent Impacts

Image credit: Chelyabinsk Region Branch of Russian Interior Ministry/HO/EPA


The prospect of Earth getting hit by a giant hunk of space rock is concerning enough that the United Nations is gathering top minds in Italy this week to discuss it.


Scientists say the idea of blowing up an asteroid — as Bruce Willis’ character did in the movie “Armageddon” — is pure Hollywood fantasy. Even if we could hit it, it’s unlikely to stop it.


Existing sky-watching programs run by NASA and others can only spot the biggest asteroids, not the small ones that sneak up on us.


But fear not, citizens of Earth. Scientists have a plan.


RELATED: Russian Meteor: Rushing to Cash in on the Blast


One group, the non-profit B612 Foundation, proposes sending a telescope, called Sentinel, into space to detect incoming objects decades before their orbits intersect ours. Then, unmanned spacecraft could fly to them and nudge them clear of Earth’s path.


The group is trying to raise $200 million to make it happen and hopes to launch the telescope by 2016.


Another project, proposed by the University of Hawaii, aims to give earthlings a heads-up when necessary, starting by 2015.


RELATED: Meteor Events: Rare, but Dangerous


It is called the Atlas program, and the plan is to deploy a string of telescopes that would search for even smaller objects in the sky, hoping to be able to give people at least a few day’s notice that could allow time for an evacuation.


Until then, better keep Bruce Willis on speed dial.



SHOWS: World News






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Wiping out top predators messes up the climate









































Wiping out top predators like lions, wolves and sharks is tragic, bad for ecosystems – and can make climate change worse. Mass extinctions of the big beasts of the jungles, grasslands and oceans could already be adding to greenhouse gases in the atmosphere.












Trisha Atwood of the University of British Columbia in Vancouver, Canada, studied the effect of removing predator fish from ponds and rivers in Canada and Costa Rica. Across a range of ecosystems, climates and predators, she found a consistent pattern: carbon dioxide emissions typically increased more than tenfold after the predators were removed.












"It looks like predators in many types of ecosystems – marine and terrestrial as well as freshwater – can play a very big role in global climate change," she told New Scientist.












The widespread and dramatic ecological impacts of the loss of top predators are well known. In the ensuing "trophic cascade", the vanished top predator's prey proliferate, which in turn puts pressure on the species that the prey eats, and so on down the food chain. In this way, changes at the top of a food chain destabilise the balance of populations right the way down.












But the geochemical impacts of trophic cascades, including any impact on emissions from ecosystems, are much less well known. Atwood's study of freshwater ecosystems showed how changes to species at the bottom of the food chain, such as photosynthesising algae, following the removal of a top predator dramatically increased the flow of CO2 from the ecosystem to the atmosphere.












The effect will not always be to increase CO2 emissions, however – sometimes the loss of top predators could decrease emissions, she says. "But we show that something so seemingly unrelated, like fishing all the trout from a pond or removing sharks from the ocean, could have big consequences for greenhouse-gas dynamics."











Help from kelp













Other recent studies have hinted at similar effects. Last October, Christopher Wilmers of the University of California, Santa Cruz, reported how the disappearance of sea otters is linked with increased CO2 emissions from North American coastlines (Frontiers in Ecology and the Environment, doi.org/khz). With no otters eating them, sea urchins thrive and eat out kelp forests – often known as the "rainforests of the oceans" – resulting in major CO2 releases.












Global climate models do not take such impacts into account yet. Atwood says they could be major, as freshwater emissions may be on a par with the influence of deforestation, which is thought responsible for around 15 per cent of human-caused CO2 emissions.












Environmentalists will herald the findings as further evidence that it is vital to protect pristine habitats and the charismatic species at the top of their food chains. But there is a dark side. A recent study found that some island ecosystems around New Zealand store 40 per cent more carbon than others because of their top predators – invading rats that are wiping out seabird colonies. Rats, it seems, are good for the climate (Biology Letters, doi.org/bbmtw9).












Journal reference: Nature Geoscience, DOI: 10.1038/NGEO1734


















































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Pakistan protesters demand end to killing of Shiites






QUETTA, Pakistan: Thousands of women refused to bury victims of a bloody bombing and a strike shut down Pakistan's biggest city Karachi as protesters across the country demanded protection for Shiite Muslims.

Up to 4,000 women began their sit-in in Quetta Sunday evening, a day after a bomb in the city killed 81 members of the minority community including nine women and two girls aged seven and nine.

The women blocked a road and refused to bury the dead until authorities take action against the extremists behind the attack, which wounded 178 people.

The bomb, containing nearly a tonne of explosives hidden in a water tanker, tore through a crowded market in Hazara Town, a Shiite-dominated area on the edge of the city on Saturday evening.

It was the second deadly blast in the city in little over a month.

The sit-in continued Monday at Hazara Town and near a local station, said Wazir Khan Nasir, police chief of Quetta which is the capital of the southwestern province of Baluchistan.

"We are going to resume negotiations with the Shiite community leaders this morning to convince them to bury the dead," Nasir told AFP.

However a local Shiite party leader, Qayyum Changezi, said the protesters "will not bury the dead until a targeted operation is launched".

UN Secretary General Ban Ki-moon strongly condemned the bomb blast and called on authorities to act quickly against those responsible.

Sit-in demonstrations were held in several cities and towns across the country demanding an end to the killing of Shiites.

Public transport drivers and traders stopped work in Karachi Monday after a Shiite party called a protest strike, residents said.

Schools were closed, traffic was off the roads and attendance in offices was thin in the city. Several political and religious parties have backed the strike call.

"We will continue our peaceful struggle for protection of the Shiite community," said a Shiite party leader, Hasan Zafar Naqvi.

Baluchistan has increasingly become a flashpoint for surging sectarian bloodshed between Pakistan's majority Sunni Muslims and Shiites, who account for around a fifth of the country's 180 million people.

Saturday's attack takes the death toll in sectarian attacks in Pakistan this year to almost 200 compared with more than 400 in the whole of 2012 -- a year which Human Rights Watch described as the deadliest on record for Shiites.

A double suicide bombing on a snooker club in Quetta on January 10 killed at least 92 people, the deadliest-ever single attack on the community in Pakistan.

No one has been arrested for that attack and Daud Agha, chairman of the Shia Conference, told AFP anger was rising in the community.

Although it is customary for Muslims to bury the dead swiftly, protesters after the snooker club bombing refused to do so, prompting Islamabad to sack the provincial government.

The banned militant group Lashkar-e-Jhangvi (LeJ) claimed responsibility for Saturday's attack -- as it did for the snooker hall bombing and a February 1 attack on a Shiite mosque in northwest Pakistan that killed 24.

There is anger and frustration at the apparent inability or unwillingness of the authorities to tackle the LeJ. Activists say the failure of the judiciary to prosecute sectarian killers allows them to operate with impunity.

Baluchistan governor Zulfiqar Magsi pointed the finger at the security forces over the latest atrocity.

"Repeated occurrence of such attacks is a failure of our intelligence agencies," he told reporters late Saturday.

"Our security institutions, police, FC (paramilitary Frontier Corps) and others are either scared or cannot take action against them."

But Baluchistan home secretary Akbar Hussain Durrani said authorities were already taking action. "Law enforcement agencies have arrested so many suspects and seized huge cache of arms," Durrani said.

Pakistan is due to hold a general election in coming months but there are fears that rising sectarian and Islamist violence could force the postponement of polls.

- AFP/ir



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Why Google's stores shouldn't look so much like Apple stores



Is this really different enough?



(Credit:
Crave CNET UK)


Some engineers have never dated a real person.


They've tried to, but it's hard for them to appreciate that real people don't necessarily use data to make decisions -- especially when it comes to love.


Perhaps their most embarrassing moments come when they try to mimic what non-engineers do in order to make themselves more attractive.


This mirrors some of the little issues that the Google brand has had over the years in becoming, well, human.


When you've spent you life believing that facts are everything, it's hard to imagine that people might prefer, oh, rounded corners or that ephemeral thing sometimes known as taste.


Google has made progress through some of its advertising. The "Jess Time" ad for Chrome was one of the very best tech ads of the 2012.


Yet when Google has wandered into retail, it has either believed that all you need is online or that an offline store ought to look rather like Apple's.


This is something against which Microsoft also struggles. It was almost comical when one Microsoft employee explained to me that its store looked -- at first glance -- a lot like the Apple store because the company used the same design firm.


This week, rumors surfaced that Google wants to make the next step in coming toward humanity by having its own shopping-mall retail presence.


The evidence so far from its pop-up stores -- as the picture above shows -- is that Google isn't thinking different. Or, at least, different enough.


If it fully intends to come out to the people -- to be itself-- then instead of having nice, clean retail staff in blue T-shirts (what brand does that remind you of?), it should embrace its true heart.


It should have real house-trained nerds, replete with bedhead and bad taste clothing, there for all to see. Yes, you could have nice, normal members of staff there to translate for them.


But the purpose of a retail store isn't merely to sell. It's to create street theater. Apple has its own version. Google must find its own too.


Instead of the now almost cliched clean lines and permanent white, it should make its stores look like excitable, sophisticated college playrooms, where books about dragons and vast Hulk hands are lying about and episodes of "Star Trek" and "Game of Thrones" are playing on huge screens.



More Technically Incorrect



It should expose itself fully as a brand that came out of nerdomania by parading its nerdomanic tendencies for all to see and making it lovable.


You might think this marginally insane. You might think that I am suffering from delusions of brandy.


Yet "The Big Bang Theory" has proved to be one of the most popular TV shows, not because the nerds are hidden away, but because they are in full view, with a beautiful counterpoint in a real person called Penny.


Imagine taking your kids, your lover, or your granny into a Google store and having them actually enjoy learning something about, say, comic books or Hermann von Helmholtz.


Imagine walking in and one of the Google nerds has dressed as The Flash, Batman, or Wonder Woman for the day, yet still finds a way to sell you a fascinating
Nexus 7.


In fact, wouldn't it be an excellent human resources idea, as well as a stimulus to make more uplifting products, if every Google engineer had to spend a certain period working in a Google retail store?


Mountain View should surely mine the more lofty, fantastic elements of its reality in order to create something unique and dramatic.


Otherwise, its stores might simply be accused of being Apple rip-offs.


And you know where that will ultimately end up. Yes, in front of Judge Lucy Koh.


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Meet the Meteorite Hunter


Michael Farmer is one of the world's only full-time meteorite hunters. Since the 1990s, the 40-year-old Tucson, Arizona, resident has been scouring the world for pieces of interstellar rock, racing to be the first one on the scene and selling his finds to museums and private collectors. On Friday, as Russians reportedly scrambled to collect fragments from a passing meteorite that injured hundreds, Farmer spoke with National Geographic about his unusual line of work.

Why are so many people in Russia busy gathering up meteorite fragments?

It's a historic event. This will be talked about forever. Everyone wants to have a little piece of it. And scientifically, we want to study it. We want to know what's out there, and we want to know how big it is, and we want to know what damage it can cause. The preliminary data from NASA's Jet Propulsion Laboratory says about 7,000 tons landed.

How many meteorite fragments are known to be on Earth?

There are a couple of hundred thousand known meteorites. Of course, there's millions and millions on the planet; we just have to find them. Most of the Earth is inhospitable—heavy forest, jungle, ocean. Meteorites that fall in the ocean are just gone, disappeared to the bottom.

How many other full-time meteorite hunters are there?

Dedicated, serious meteorite hunters? There are maybe 20 of us. If you add in the part-timers who go somewhere whenever [an impact is] close to them, then you might approach a hundred.

How did you become a meteorite hunter?

Here in Tucson right now we have the world's biggest mineral show going on. I bought a meteorite at this very same show 20 years ago, and I was absolutely obsessed and hooked. Since then I've been around the world more times than I can count—four million miles on American Airlines alone.

How many countries have you been to?

About 70 countries, by my last count. About 50, 59 trips to Africa—a lot of work in Africa. The Sahara and other deserts there make meteorites easier to find than on other terrains, and also keep them well preserved.

What are the challenges you face when you're on a hunt?

Well, you're usually going into a kind of chaotic scene where nobody really knows much. In Africa and other places I go [the locals] don't usually understand what's happening, and most of the time they don't care. They're more concerned with eating that day. But the instant some guy shows up and says, "I'll pay you to find this rock," the whole village empties—and then lots of rocks show up.

Related: Best Meteorites for Tourists

It can be dangerous work. I've been robbed, put into prison. For example, I was in prison two years ago in the Middle East, in Oman—actually sentenced, convicted, and put in prison for three months for "illegal mining activity." Not a very nice time. And the same year, 2011, in the fall I went to Kenya three times, after a major meteorite fell. On the third trip over I had a robbery where they ambushed us and almost murdered me. I was down on my knees, with a bag over my head and a machete on my throat and a gun at my head, being beaten. Luckily they decided to just take everything and leave instead of killing us. It's a dangerous line of work because it involves money, and people want that money.

What's the most valuable meteorite you've found?

Well, I've found three separate moon rocks in the Middle East. [Moon rocks are considered a type of meteorite that came loose from the lunar surface and fell to Earth.] And one of them I sold for $100,000 a week later. It was just a small piece—the size of a walnut. But the best meteorite I found was with my three partners up in Canada. It was actually discovered in 1931, but we went back to the location and discovered 53 kilograms [117 pounds] more. It's an extremely rare type of meteorite called a pallasite, and it's about 4.5 billion years old. We sold it to the Canadian government for just under a million dollars. Now it's in the Royal Ontario Museum, in Toronto, and it's considered a national treasure.

Where else do you sell your wares?

Well, I do shows around the world, in France, Germany, Japan. I go to expos, like this one here in Tucson, which is the biggest mineral show in the world and lasts for three weeks. And museums are always calling me.

Related: Archival Photos of Meteorite Recovery

It's a small market. It's not like I need a shop or anything. People call me or email me or go to my website and check it out. The market these days is so ravenous for anything new that when I get a new meteorite, it's usually sold in hours. I don't even have to work anymore. I just make phone calls to a few people, and it's all gone.

Where do you store your collection?

I have multiple storage sites—never put all your eggs in one basket. And I have lots of bulk material. Sometimes I buy this stuff by the ton, and it goes into storage and I sell it off one piece at a time.

What's the verification process like?

Any meteorite, anything that we want to have an official name, has to go to a laboratory, where it gets sectioned and studied by scientists. For example, I'd guess this meteorite in Russia yesterday will be in a lab in Moscow, being researched within hours.

Related: History's Big Meteorite Crashes

In the collector market, we work collaboratively with the scientists. I supply them with rocks, and they supply me with data, both of which I need to make money. People want to know what something is before they buy it.

Are there legal or ethical implications to meteorite hunting?

There always are. Certain countries have passed laws. But when I was arrested in Oman, they actually had no law—they were just very upset that we were taking lots of meteorites. The only law they could charge us with was illegal mining operations—basically running a company in the country without government licensing. But I won on appeal because we had no mining equipment. We were picking up rocks off the surface of the desert. And a judge said, "If a child could do it, then it's not mining." And I was immediately released and sent home.

But there's always friction between the collecting market and the scientific market. There are scientists out there who believe that no meteorite should be in private hands. Well, I tell you, I've been on hunts all over the world and I've only run into scientists a couple of times. They don't have the time or money to do it. So if it wasn't for us, 99 percent of these meteorites would be lost to science.

What about this meteorite strike—do you think scientists will go to Russia?

I guarantee there'll be scientists from everywhere in the world going to this one.

Are you catching the next flight to Moscow?

Well, of course as a meteorite dealer, I want to own this. I woke up this morning to a hundred e-mails from people begging me to get on a plane and go get it so they can buy a piece.

But I'm probably not going. Getting into Russia can be complicated. I'll just buy some from the Russians when it comes out.

Of course, if this had happened in China or somewhere in Africa, I'd be packing my bags right now and getting on a plane, figuring it all out when I get there.


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Country Star Mindy McCready Shot Herself, Cops Say











Mindy McCready, the country singer who soared to the top of the charts with her debut album, "Ten Thousand Angels," but struggled with substance abuse, served time in jail and fought a lengthy battle with her mother over custody of her son has died of what appears to be a self-inflicted gunshot wound, police said. She was 37.


Deputies from the Cleburne County Sheriff's Office were dispatched to a report of gun shots fired at McCready's Heber Springs, Ark., home at around 3:30 p.m. today.


There they found McCready on the front porch. She was pronounced dead at the scene from what appeared to be a single self-inflicted gunshot wound, according to a statement from the sheriff's office.


McCready's boyfriend, David Wilson, died in January of a self-inflicted gunshot wound. McCready was ordered to enter rehab shortly after Wilson's death, and her two children, Zander, 6, and 9-month-old Zayne were taken from her. She was released after one day to undergo outpatient care.


McCready scored a number-one Billboard country hit in 1996 with "Guys Do It All the Time," but in recent years, the country crooner has received more media attention for her troubled personal life than her music.


She has been arrested multiple times on drug charges and probation violations and has been hospitalized for overdoses several times, including in 2010, when she was found unconscious at her mother's home after taking a painkiller and muscle relaxant.






Angela Weiss/Getty Images







Her mother, Gayle Inge, was appointed to be her son Zander's legal guardian in 2007 after McCready was arrested for violating probation on a drug-related charge. The boy's father is McCready's ex-boyfriend Billy McKnight.


Following a custody hearing in May 2011, McCready released a statement, saying, "We have progressed in a positive manner to reunite me and my son, Zander. I feel very optimistic this will happen in the near future."


But just six months later, in November 2011, was accused of violating a court order for failing to bring Zander back to her mother in Florida after a visit. The boy was placed in foster care while McCready and her mother worked out the custody dispute.


McCready's struggle with substance abuse was broadcast in 2010 on the third season of "Celebrity Rehab with Dr. Drew."


McCready also claimed to have carried on a decade-long affair with baseball star Roger Clemens that began was she was 15 years old and he was 28. Clemens denied that the relationship was sexual in nature.


"You know what, I don't think I'm ever going to be one of those people that has a normal, quiet existence," McCready told ABC Radio in 2010. "I've been chosen for some reason to be bigger and larger than life in every way. Negative and positive."


McCready, who was born and raised in southern Florida, moved to Nashville when she was 18 to start her music career.


Within a few months, she was starting to work with producer David Malloy, who got her tapes to RLG Records. The company signed her to a contract after seeing her in concert, giving her a record deal less than a year after her arrival in Nashville.


Her debut album, "Ten Thousand Angels," went gold within six months of its release in April 1996, and eventually went multi-platinum. Two more followed: "If I Don't Stay the Night," in 1997; and "I'm Not So Tough" in 1999.


Her most recent album, "I'm Still Here," featuring new versions of her early hits "Ten Thousand Angels" and "Guys Do It All the Time," was released in March 2010.



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False memories prime immune system for future attacks









































IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.












When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.












Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.












The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.












The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."












So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.












To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).












The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.












"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"












This article appeared in print under the headline "False memories prime our defences"




















































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